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Neuropathic pain is a complex, chronic pain condition resulting from damage or dysfunction in the nervous system, either peripheral nerves or the central nervous system . Neuropathic pain originates from abnormal nerve signaling and can cause burning, shooting, or electric shock-like sensations. Common causes include diabetes, shingles, multiple sclerosis, spinal cord injury, and nerve compression. Patients may also experience tingling, numbness, and hypersensitivity to stimuli that are normally not painful.
Neuropathic pain is often difficult to treat and typically requires a multidisciplinary intervention:
First-line medications include anticonvulsants, antidepressants, and topical agents.
Such as physical therapy, cognitive-behavioral therapy, and transcutaneous electrical nerve stimulation (TENS).
Nerve blocks or spinal cord stimulation may be considered for refractory cases.
Ketamine, an NMDA receptor antagonist, can treat neuropathic pain by blocking excitatory glutamate signalling involved in central sensitization. This is a a condition where the central nervous system (brain and spinal cord) becomes “stuck” in a state of high reactivity, acting like a broken, oversensitive alarm system. This is common in patients with chronic pain. Ketamine infusions can reduce the pain intensity in patients who don’t respond to conventional treatments.
Jacobs Pain Centre, 8920 Woodbine Ave, Unit 102, Markham, ON L3R 9W9
Since 2002, Jacobs Pain Centre has provided effective, comprehensive pain management through a multidisciplinary approach. We combine evidence-based treatments with supportive care to deliver accurate diagnoses and personalized pain management plans.
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